The wait is almost over for fans of Grey’s Anatomy, as ABC has confirmed the official return of the long-running medical drama. With 21 seasons already behind it, the iconic series is set to debut season 22 this fall, bringing back both emotional storylines and fan-favorite characters.
Grey’s Anatomy Season 22 Release Date and Time
Grey’s Anatomy season 22 will premiere on Thursday, October 9, 2025, at 10:00 PM ET/PT on ABC. The new season will feature 18 episodes, airing weekly in the same primetime slot.
After episodes air on ABC, they will be available for next-day streaming on Hulu and Hulu on Disney+, making it easy for fans to catch up.
Where Grey’s Anatomy Season 21 Left Off
Season 21 ended with a dramatic cliffhanger: a bomb exploding inside Grey Sloan Memorial Hospital. While Meredith Grey (Ellen Pompeo), Ben Warren (Jason George), and Jo Wilson (Camilla Luddington) are believed to be safe, other beloved characters may not have been so lucky. The fallout from this event is expected to play a central role in the upcoming season.
Returning Cast Members for Grey’s Anatomy Season 22
The ensemble cast for season 22 includes both familiar faces and returning favorites:
- Ellen Pompeo as Meredith Grey (also executive producer)
- Chandra Wilson as Dr. Miranda Bailey
- James Pickens Jr. as Dr. Richard Webber
- Kevin McKidd as Dr. Owen Hunt
- Kim Raver as Dr. Teddy Altman
- Caterina Scorsone as Dr. Amelia Shepherd
- Camilla Luddington as Dr. Jo Wilson
- Anthony Hill as Dr. Winston Ndugu
- Adelaide Kane as Jules Millin
- Alexis Floyd as Simone Griffith
In one of the most exciting reveals, Patrick Dempsey will reprise his role as Derek Shepherd for at least seven episodes, marking a major return for longtime fans of the series.
What to Expect in Grey’s Anatomy Season 22?
While ABC has not yet released a trailer, the aftermath of the hospital bombing promises high-stakes drama and emotional fallout. The writers are expected to balance medical cases, personal struggles, and romance, a formula that has kept the show going strong for nearly two decades.
Final Thoughts
With its official return date set, Grey’s Anatomy season 22 is already one of the most anticipated TV premieres of the fall lineup. Between shocking cliffhangers, new dynamics, and the return of beloved characters, the season promises to keep viewers glued to their screens.
Grey’s Anatomy season 22 premieres October 9, 2025, on ABC, with streaming available the following day on Hulu and Hulu on Disney+.
Are you excited for the return of Meredith Grey and the rest of the Grey Sloan team? Share your predictions for season 22 in the comments and keep following InvestRecords.com for the latest TV news and updates.